Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex(1)

AIMS: Loss-of-function mutations in Calsequestrin 2 (CASQ2) are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT patients also exhibit bradycardia and atrial arrhythmias for which the underlying mechanism remains unknown. We aimed to study the sinoatrial node (SAN)...

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Vydáno v:Eur Heart J
Hlavní autoři: Glukhov, Alexey V., Kalyanasundaram, Anuradha, Lou, Qing, Hage, Lori T., Hansen, Brian J., Belevych, Andriy E., Mohler, Peter J., Knollmann, Björn C., Periasamy, Muthu, Györke, Sandor, Fedorov, Vadim V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Basic Science
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359358/
https://ncbi.nlm.nih.gov/pubmed/24216388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/eht452
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