Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex(1)

AIMS: Loss-of-function mutations in Calsequestrin 2 (CASQ2) are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT patients also exhibit bradycardia and atrial arrhythmias for which the underlying mechanism remains unknown. We aimed to study the sinoatrial node (SAN)...

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Detalhes bibliográficos
Publicado no:Eur Heart J
Main Authors: Glukhov, Alexey V., Kalyanasundaram, Anuradha, Lou, Qing, Hage, Lori T., Hansen, Brian J., Belevych, Andriy E., Mohler, Peter J., Knollmann, Björn C., Periasamy, Muthu, Györke, Sandor, Fedorov, Vadim V.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359358/
https://ncbi.nlm.nih.gov/pubmed/24216388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/eht452
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