Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex(1)

AIMS: Loss-of-function mutations in Calsequestrin 2 (CASQ2) are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT patients also exhibit bradycardia and atrial arrhythmias for which the underlying mechanism remains unknown. We aimed to study the sinoatrial node (SAN)...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Eur Heart J
Main Authors: Glukhov, Alexey V., Kalyanasundaram, Anuradha, Lou, Qing, Hage, Lori T., Hansen, Brian J., Belevych, Andriy E., Mohler, Peter J., Knollmann, Björn C., Periasamy, Muthu, Györke, Sandor, Fedorov, Vadim V.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Basic Science
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359358/
https://ncbi.nlm.nih.gov/pubmed/24216388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/eht452
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