Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex(1)

AIMS: Loss-of-function mutations in Calsequestrin 2 (CASQ2) are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT patients also exhibit bradycardia and atrial arrhythmias for which the underlying mechanism remains unknown. We aimed to study the sinoatrial node (SAN)...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Eur Heart J
Egile Nagusiak: Glukhov, Alexey V., Kalyanasundaram, Anuradha, Lou, Qing, Hage, Lori T., Hansen, Brian J., Belevych, Andriy E., Mohler, Peter J., Knollmann, Björn C., Periasamy, Muthu, Györke, Sandor, Fedorov, Vadim V.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2015
Gaiak:
Basic Science
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359358/
https://ncbi.nlm.nih.gov/pubmed/24216388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/eht452
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