Bis-Aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors

The discovery/optimization of bis-aryl ureas as Limk inhibitors to obtain high potency and selectivity, and appropriate pharmacokinetic properties through systematic SAR studies is reported. Docking studies supported the observed SAR. Optimized Limk inhibitors had high biochemical potency (IC(50) &l...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :J Med Chem
Главные авторы: Yin, Yan, Zheng, Ke, Eid, Nibal, Howard, Shannon, Jeong, Ji-Hak, Yi, Fei, Guo, Jia, Park, Chul M, Bibian, Mathieu, Wu, Weilin, Hernandez, Pamela, Park, HaJeung, Wu, Yuntao, Luo, Jun-Li, LoGrasso, Philip V., Feng, Yangbo
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349585/
https://ncbi.nlm.nih.gov/pubmed/25621531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501680m
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы