Bis-Aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors

The discovery/optimization of bis-aryl ureas as Limk inhibitors to obtain high potency and selectivity, and appropriate pharmacokinetic properties through systematic SAR studies is reported. Docking studies supported the observed SAR. Optimized Limk inhibitors had high biochemical potency (IC(50) &l...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Yin, Yan, Zheng, Ke, Eid, Nibal, Howard, Shannon, Jeong, Ji-Hak, Yi, Fei, Guo, Jia, Park, Chul M, Bibian, Mathieu, Wu, Weilin, Hernandez, Pamela, Park, HaJeung, Wu, Yuntao, Luo, Jun-Li, LoGrasso, Philip V., Feng, Yangbo
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349585/
https://ncbi.nlm.nih.gov/pubmed/25621531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501680m
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