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Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats
[Image: see text] A series of urea-based Rho kinase (ROCK) inhibitors were designed and evaluated. The discovered compounds had excellent enzyme and cellular potency, high kinase selectivity, high aqueous solubility, good porcine corneal penetration, and appropriate DMPK profiles for topical applica...
সংরক্ষণ করুন:
| প্রধান লেখক: | , , , , , , , , , , , |
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| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
American Chemical Society
2010
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| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4007833/ https://ncbi.nlm.nih.gov/pubmed/24900192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1000382 |
| ট্যাগগুলো: |
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