Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats

[Image: see text] A series of urea-based Rho kinase (ROCK) inhibitors were designed and evaluated. The discovered compounds had excellent enzyme and cellular potency, high kinase selectivity, high aqueous solubility, good porcine corneal penetration, and appropriate DMPK profiles for topical applica...

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Hauptverfasser: Yin, Yan, Cameron, Michael D., Lin, Li, Khan, Susan, Schröter, Thomas, Grant, Wayne, Pocas, Jennifer, Chen, Yen Ting, Schürer, Stephan, Pachori, Alok, LoGrasso, Philip, Feng, Yangbo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2010
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007833/
https://ncbi.nlm.nih.gov/pubmed/24900192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1000382
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