Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats

[Image: see text] A series of urea-based Rho kinase (ROCK) inhibitors were designed and evaluated. The discovered compounds had excellent enzyme and cellular potency, high kinase selectivity, high aqueous solubility, good porcine corneal penetration, and appropriate DMPK profiles for topical applica...

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Hlavní autoři: Yin, Yan, Cameron, Michael D., Lin, Li, Khan, Susan, Schröter, Thomas, Grant, Wayne, Pocas, Jennifer, Chen, Yen Ting, Schürer, Stephan, Pachori, Alok, LoGrasso, Philip, Feng, Yangbo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2010
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007833/
https://ncbi.nlm.nih.gov/pubmed/24900192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1000382
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