Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats

[Image: see text] A series of urea-based Rho kinase (ROCK) inhibitors were designed and evaluated. The discovered compounds had excellent enzyme and cellular potency, high kinase selectivity, high aqueous solubility, good porcine corneal penetration, and appropriate DMPK profiles for topical applica...

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Xehetasun bibliografikoak
Egile Nagusiak: Yin, Yan, Cameron, Michael D., Lin, Li, Khan, Susan, Schröter, Thomas, Grant, Wayne, Pocas, Jennifer, Chen, Yen Ting, Schürer, Stephan, Pachori, Alok, LoGrasso, Philip, Feng, Yangbo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2010
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007833/
https://ncbi.nlm.nih.gov/pubmed/24900192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1000382
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