Structure and immune recognition of trimeric prefusion HIV-1 Env

The HIV-1-envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates, to a postfusion state. As the sole viral antigen on the HIV-1-virion surface,...

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Publicado no:Nature
Main Authors: Pancera, Marie, Zhou, Tongqing, Druz, Aliaksandr, Georgiev, Ivelin S., Soto, Cinque, Gorman, Jason, Huang, Jinghe, Acharya, Priyamvada, Chuang, Gwo-Yu, Ofek, Gilad, Stewart-Jones, Guillaume B. E., Stuckey, Jonathan, Bailer, Robert T., Joyce, M. Gordon, Louder, Mark K., Tumba, Nancy, Yang, Yongping, Zhang, Baoshan, Cohen, Myron S., Haynes, Barton F., Mascola, John R., Morris, Lynn, Munro, James B., Blanchard, Scott C., Mothes, Walther, Connors, Mark, Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348022/
https://ncbi.nlm.nih.gov/pubmed/25296255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13808
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