Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

The HIV-1 envelope (Env) trimer is a target for vaccine design as well as a conformational machine that facilitates virus entry by transitioning between prefusion-closed, CD4-bound, and coreceptor-bound conformations by transitioning into a postfusion state. Vaccine designers have sought to restrict...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Chuang, Gwo-Yu, Geng, Hui, Pancera, Marie, Xu, Kai, Cheng, Cheng, Acharya, Priyamvada, Chambers, Michael, Druz, Aliaksandr, Tsybovsky, Yaroslav, Wanninger, Timothy G., Yang, Yongping, Doria-Rose, Nicole A., Georgiev, Ivelin S., Gorman, Jason, Joyce, M. Gordon, O'Dell, Sijy, Zhou, Tongqing, McDermott, Adrian B., Mascola, John R., Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411596/
https://ncbi.nlm.nih.gov/pubmed/28275193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02268-16
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