Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition

Over the past decade, structures have been determined for broadly neutralizing antibodies that recognize all major exposed surfaces of the prefusion-closed HIV-1-envelope (Env) trimer. Here we analyze 206 antibody-HIV-1 Env structures from the Protein Data Bank with resolution suitable to define int...

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Udgivet i:Structure
Main Authors: Chuang, Gwo-Yu, Zhou, Jing, Acharya, Priyamvada, Rawi, Reda, Shen, Chen-Hsiang, Sheng, Zizhang, Zhang, Baoshan, Zhou, Tongqing, Bailer, Robert T., Dandey, Venkata P., Doria-Rose, Nicole A., Louder, Mark K., McKee, Krisha, Mascola, John R., Shapiro, Lawrence, Kwong, Peter D.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664815/
https://ncbi.nlm.nih.gov/pubmed/30471922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.10.007
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