MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis

BACKGROUND AND PURPOSE: MLN4924 prevents the formation of active cullin-RING ubiquitin ligase complexes and thus inhibits NF-κB signalling. Here, we evaluated the effects of this compound on monocytes and dendritic cells (DCs). EXPERIMENTAL APPROACH: Monocytes and DCs were challenged with TNF or LPS...

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Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: El-Mesery, Mohamed, Seher, Axel, Stühmer, Thorsten, Siegmund, Daniela, Wajant, Harald
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BlackWell Publishing Ltd 2015
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337697/
https://ncbi.nlm.nih.gov/pubmed/25363690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12998
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