SMAC Mimetic BV6 Induces Cell Death in Monocytes and Maturation of Monocyte-Derived Dendritic Cells

BACKGROUND: Compounds mimicking the inhibitory effect of SMAC / DIABLO on X-linked inhibitor of apoptosis (XIAP) have been developed with the aim to achieve sensitization for apoptosis of tumor cells resistant due to deregulated XIAP expression. It turned out that SMAC mimetics also have complex eff...

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Autori principali: Müller-Sienerth, Nicole, Dietz, Lena, Holtz, Philipp, Kapp, Markus, Grigoleit, Götz Ulrich, Schmuck, Carsten, Wajant, Harald, Siegmund, Daniela
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127953/
https://ncbi.nlm.nih.gov/pubmed/21738708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021556
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