The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis

BACKGROUND: In the present study, we aimed to investigate the effect of counteracting inhibitor of apoptosis (IAP) proteins using the small molecule Second Mitochondria-derived Activator of Caspase (SMAC) mimetic BV6 in combination with ionizing radiation on apoptosis, cell cycle regulation, DNA dou...

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Detalhes bibliográficos
Publicado no:Radiat Oncol
Main Authors: Hehlgans, Stephanie, Oppermann, Julius, Reichert, Sebastian, Fulda, Simone, Rödel, Claus, Rödel, Franz
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573682/
https://ncbi.nlm.nih.gov/pubmed/26383618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13014-015-0507-4
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