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MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis
BACKGROUND AND PURPOSE: MLN4924 prevents the formation of active cullin-RING ubiquitin ligase complexes and thus inhibits NF-κB signalling. Here, we evaluated the effects of this compound on monocytes and dendritic cells (DCs). EXPERIMENTAL APPROACH: Monocytes and DCs were challenged with TNF or LPS...
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| Udgivet i: | Br J Pharmacol |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BlackWell Publishing Ltd
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4337697/ https://ncbi.nlm.nih.gov/pubmed/25363690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12998 |
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