MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors

MicroRNAs (miRNAs) are key regulators of hematopoietic cell differentiation and may contribute to altered growth of leukemic stem cells. Using microarray-based miRNA profiling, we found that miRNA 486 (miR-486) is significantly upregulated in chronic myeloid leukemia (CML) compared with normal CD34(...

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Veröffentlicht in:Blood
Hauptverfasser: Wang, Li-Sheng, Li, Ling, Li, Liang, Chu, Su, Shiang, Keh-Dong, Li, Min, Sun, Hui-Yan, Xu, Jun, Xiao, Feng-Jun, Sun, Guihua, Rossi, John J., Ho, YinWei, Bhatia, Ravi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2015
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335083/
https://ncbi.nlm.nih.gov/pubmed/25515961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-581926
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