Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems

BACKGROUND: The DNA methylation profiles of mammalian cell lines differ from those of the primary tissues from which they were derived, exhibiting increasing divergence from the in vivo methylation profile with extended time in culture. Few studies have directly examined the initial epigenetic and t...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Nestor, Colm E, Ottaviano, Raffaele, Reinhardt, Diana, Cruickshanks, Hazel A, Mjoseng, Heidi K, McPherson, Rhoanne C, Lentini, Antonio, Thomson, John P, Dunican, Donncha S, Pennings, Sari, Anderton, Stephen M, Benson, Mikael, Meehan, Richard R
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334405/
https://ncbi.nlm.nih.gov/pubmed/25648825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0576-y
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