Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems

BACKGROUND: The DNA methylation profiles of mammalian cell lines differ from those of the primary tissues from which they were derived, exhibiting increasing divergence from the in vivo methylation profile with extended time in culture. Few studies have directly examined the initial epigenetic and t...

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書目詳細資料
發表在:Genome Biol
Main Authors: Nestor, Colm E, Ottaviano, Raffaele, Reinhardt, Diana, Cruickshanks, Hazel A, Mjoseng, Heidi K, McPherson, Rhoanne C, Lentini, Antonio, Thomson, John P, Dunican, Donncha S, Pennings, Sari, Anderton, Stephen M, Benson, Mikael, Meehan, Richard R
格式: Artigo
語言:Inglês
出版: BioMed Central 2015
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334405/
https://ncbi.nlm.nih.gov/pubmed/25648825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0576-y
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