Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems

BACKGROUND: The DNA methylation profiles of mammalian cell lines differ from those of the primary tissues from which they were derived, exhibiting increasing divergence from the in vivo methylation profile with extended time in culture. Few studies have directly examined the initial epigenetic and t...

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Detalles Bibliográficos
Publicado en:Genome Biol
Main Authors: Nestor, Colm E, Ottaviano, Raffaele, Reinhardt, Diana, Cruickshanks, Hazel A, Mjoseng, Heidi K, McPherson, Rhoanne C, Lentini, Antonio, Thomson, John P, Dunican, Donncha S, Pennings, Sari, Anderton, Stephen M, Benson, Mikael, Meehan, Richard R
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2015
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334405/
https://ncbi.nlm.nih.gov/pubmed/25648825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0576-y
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