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Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems
BACKGROUND: The DNA methylation profiles of mammalian cell lines differ from those of the primary tissues from which they were derived, exhibiting increasing divergence from the in vivo methylation profile with extended time in culture. Few studies have directly examined the initial epigenetic and t...
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| 出版年: | Genome Biol |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2015
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4334405/ https://ncbi.nlm.nih.gov/pubmed/25648825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0576-y |
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