Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems

BACKGROUND: The DNA methylation profiles of mammalian cell lines differ from those of the primary tissues from which they were derived, exhibiting increasing divergence from the in vivo methylation profile with extended time in culture. Few studies have directly examined the initial epigenetic and t...

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Vydáno v:Genome Biol
Hlavní autoři: Nestor, Colm E, Ottaviano, Raffaele, Reinhardt, Diana, Cruickshanks, Hazel A, Mjoseng, Heidi K, McPherson, Rhoanne C, Lentini, Antonio, Thomson, John P, Dunican, Donncha S, Pennings, Sari, Anderton, Stephen M, Benson, Mikael, Meehan, Richard R
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334405/
https://ncbi.nlm.nih.gov/pubmed/25648825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0576-y
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