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Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline

Mouse primordial germ cells (PGCs) erase global DNA methylation (5mC) as part of the comprehensive epigenetic reprogramming that occurs during PGC development. 5mC plays an important role in maintaining stable gene silencing and repression of transposable elements (TE) but it is not clear how the ex...

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מידע ביבליוגרפי
Main Authors: Hackett, Jamie A., Reddington, James P., Nestor, Colm E., Dunican, Donncha S., Branco, Miguel R., Reichmann, Judith, Reik, Wolf, Surani, M. Azim, Adams, Ian R., Meehan, Richard R.
פורמט: Artigo
שפה:Inglês
יצא לאור: Company of Biologists 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436114/
https://ncbi.nlm.nih.gov/pubmed/22949617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.081661
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