Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes

Mouse embryonic stem cells (mESCs) cultured with MEK/ERK and GSK3β (2i) inhibitors transition to ground state pluripotency. Gene expression changes, redistribution of histone H3K27me3 profiles and global DNA hypomethylation are hallmarks of 2i exposure, but it is unclear whether epigenetic alteratio...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Shukla, Ruchi, Mjoseng, Heidi K, Thomson, John P, Kling, Simon, Sproul, Duncan, Dunican, Donncha S, Ramsahoye, Bernard, Wongtawan, Tuempong, Treindl, Fridolin, Templin, Markus F, Adams, Ian R, Pennings, Sari, Meehan, Richard R
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641322/
https://ncbi.nlm.nih.gov/pubmed/32585002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa529
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