Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes

Mouse embryonic stem cells (mESCs) cultured with MEK/ERK and GSK3β (2i) inhibitors transition to ground state pluripotency. Gene expression changes, redistribution of histone H3K27me3 profiles and global DNA hypomethylation are hallmarks of 2i exposure, but it is unclear whether epigenetic alteratio...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Nucleic Acids Res
Päätekijät: Shukla, Ruchi, Mjoseng, Heidi K, Thomson, John P, Kling, Simon, Sproul, Duncan, Dunican, Donncha S, Ramsahoye, Bernard, Wongtawan, Tuempong, Treindl, Fridolin, Templin, Markus F, Adams, Ian R, Pennings, Sari, Meehan, Richard R
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2020
Aiheet:
Gene regulation, Chromatin and Epigenetics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641322/
https://ncbi.nlm.nih.gov/pubmed/32585002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa529
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