Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer

LINE-1 retrotransposons are abundant repetitive elements of viral origin, which in normal cells are kept quiescent through epigenetic mechanisms. Activation of LINE-1 occurs frequently in cancer and can enable LINE-1 mobilization but also has retrotransposition-independent consequences. We previousl...

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Detalhes bibliográficos
Main Authors: Cruickshanks, Hazel A., Vafadar-Isfahani, Natasha, Dunican, Donncha S., Lee, Andy, Sproul, Duncan, Lund, Jonathan N., Meehan, Richard R., Tufarelli, Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737543/
https://ncbi.nlm.nih.gov/pubmed/23703216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt438
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