Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes

Mouse embryonic stem cells (mESCs) cultured with MEK/ERK and GSK3β (2i) inhibitors transition to ground state pluripotency. Gene expression changes, redistribution of histone H3K27me3 profiles and global DNA hypomethylation are hallmarks of 2i exposure, but it is unclear whether epigenetic alteratio...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Shukla, Ruchi, Mjoseng, Heidi K, Thomson, John P, Kling, Simon, Sproul, Duncan, Dunican, Donncha S, Ramsahoye, Bernard, Wongtawan, Tuempong, Treindl, Fridolin, Templin, Markus F, Adams, Ian R, Pennings, Sari, Meehan, Richard R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Gene regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641322/
https://ncbi.nlm.nih.gov/pubmed/32585002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa529
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