Reactive γ-Ketoaldehydes Promote Protein Misfolding and Preamyloid Oligomer Formation in Rapidly-Activated Atrial Cells

Rapid activation causes remodeling of atrial myocytes resembling that which occurs in experimental and human atrial fibrillation (AF). Using this cellular model, we previously observed transcriptional upregulation of proteins implicated in protein misfolding and amyloidosis. For organ-specific amylo...

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Bibliografiske detaljer
Udgivet i:J Mol Cell Cardiol
Main Authors: Sidorova, Tatiana N., Yermalitskaya, Liudmila V., Mace, Lisa C., Wells, K. Sam, Boutaud, Olivier, Prinsen, Joseph K., Davies, Sean S., Roberts, L. Jackson, Dikalov, Sergey I., Glabe, Charles G., Amarnath, Venkataraman, Barnett, Joey V., Murray, Katherine T.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302000/
https://ncbi.nlm.nih.gov/pubmed/25463275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.11.013
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