Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure

RATIONALE: Disrupted proteostasis is one major pathological trait that heart failure (HF) shares with other organ proteinopathies, such as Alzheimer’s and Parkinson’s diseases. Yet, differently from the latter, whether and how cardiac preamyloid oligomers (PAOs) develop in acquired forms of HF is un...

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Publicat a:Circ Res
Autors principals: Rainer, Peter P., Dong, Peihong, Sorge, Matteo, Fert-Bober, Justyna, Holewinski, Ronald J., Wang, Yuchuan, Foss, Catherine A., An, Steven S., Baracca, Alessandra, Solaini, Giancarlo, Glabe, Charles G., Pomper, Martin G., Van Eyk, Jennifer E., Tomaselli, Gordon F., Paolocci, Nazareno, Agnetti, Giulio
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948147/
https://ncbi.nlm.nih.gov/pubmed/29483093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.312082
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