Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure

RATIONALE: Disrupted proteostasis is one major pathological trait that heart failure (HF) shares with other organ proteinopathies, such as Alzheimer’s and Parkinson’s diseases. Yet, differently from the latter, whether and how cardiac preamyloid oligomers (PAOs) develop in acquired forms of HF is un...

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Publicado no:Circ Res
Main Authors: Rainer, Peter P., Dong, Peihong, Sorge, Matteo, Fert-Bober, Justyna, Holewinski, Ronald J., Wang, Yuchuan, Foss, Catherine A., An, Steven S., Baracca, Alessandra, Solaini, Giancarlo, Glabe, Charles G., Pomper, Martin G., Van Eyk, Jennifer E., Tomaselli, Gordon F., Paolocci, Nazareno, Agnetti, Giulio
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948147/
https://ncbi.nlm.nih.gov/pubmed/29483093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.312082
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