Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure

RATIONALE: Disrupted proteostasis is one major pathological trait that heart failure (HF) shares with other organ proteinopathies, such as Alzheimer’s and Parkinson’s diseases. Yet, differently from the latter, whether and how cardiac preamyloid oligomers (PAOs) develop in acquired forms of HF is un...

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Pubblicato in:Circ Res
Autori principali: Rainer, Peter P., Dong, Peihong, Sorge, Matteo, Fert-Bober, Justyna, Holewinski, Ronald J., Wang, Yuchuan, Foss, Catherine A., An, Steven S., Baracca, Alessandra, Solaini, Giancarlo, Glabe, Charles G., Pomper, Martin G., Van Eyk, Jennifer E., Tomaselli, Gordon F., Paolocci, Nazareno, Agnetti, Giulio
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948147/
https://ncbi.nlm.nih.gov/pubmed/29483093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.312082
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