Reactive γ-Ketoaldehydes Promote Protein Misfolding and Preamyloid Oligomer Formation in Rapidly-Activated Atrial Cells

Rapid activation causes remodeling of atrial myocytes resembling that which occurs in experimental and human atrial fibrillation (AF). Using this cellular model, we previously observed transcriptional upregulation of proteins implicated in protein misfolding and amyloidosis. For organ-specific amylo...

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Publicat a:J Mol Cell Cardiol
Autors principals: Sidorova, Tatiana N., Yermalitskaya, Liudmila V., Mace, Lisa C., Wells, K. Sam, Boutaud, Olivier, Prinsen, Joseph K., Davies, Sean S., Roberts, L. Jackson, Dikalov, Sergey I., Glabe, Charles G., Amarnath, Venkataraman, Barnett, Joey V., Murray, Katherine T.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302000/
https://ncbi.nlm.nih.gov/pubmed/25463275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.11.013
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