Reactive γ-Ketoaldehydes Promote Protein Misfolding and Preamyloid Oligomer Formation in Rapidly-Activated Atrial Cells

Rapid activation causes remodeling of atrial myocytes resembling that which occurs in experimental and human atrial fibrillation (AF). Using this cellular model, we previously observed transcriptional upregulation of proteins implicated in protein misfolding and amyloidosis. For organ-specific amylo...

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Publié dans:J Mol Cell Cardiol
Auteurs principaux: Sidorova, Tatiana N., Yermalitskaya, Liudmila V., Mace, Lisa C., Wells, K. Sam, Boutaud, Olivier, Prinsen, Joseph K., Davies, Sean S., Roberts, L. Jackson, Dikalov, Sergey I., Glabe, Charles G., Amarnath, Venkataraman, Barnett, Joey V., Murray, Katherine T.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302000/
https://ncbi.nlm.nih.gov/pubmed/25463275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.11.013
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