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Synthesis, Pharmacological Evaluation and Molecular Modeling Studies of Triazole Containing Dopamine D(3) Receptor Ligands
A series of 2-methoxyphenyl piperazine analogues containing a triazole ring were synthesized and their in vitro binding affinities at human dopamine D(2) and D(3) receptors were evaluated. Compounds 5b, 5c, 5d, and 4g, demonstrate high affinity for dopamine D(3) receptors and moderate selectivity fo...
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| Publicado no: | Bioorg Med Chem Lett |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4297516/ https://ncbi.nlm.nih.gov/pubmed/25556097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.12.023 |
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