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Evidence for an Elevated Aspartate pK(a) in the Active Site of Human Aromatase
Aromatase (CYP19A1), the enzyme that converts androgens to estrogens, is of significant mechanistic and therapeutic interest. Crystal structures and computational studies of this enzyme shed light on the critical role of Asp(309) in substrate binding and catalysis. These studies predicted an elevate...
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| Publicat a: | J Biol Chem |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4294484/ https://ncbi.nlm.nih.gov/pubmed/25425647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.595108 |
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