Dynamics and Flexibility of Human Aromatase Probed by FTIR and Time Resolved Fluorescence Spectroscopy

Human aromatase (CYP19A1) is a steroidogenic cytochrome P450 converting androgens into estrogens. No ligand-free crystal structure of the enzyme is available to date. The crystal structure in complex with the substrate androstenedione and the steroidal inhibitor exemestane shows a very compact confo...

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Bibliographic Details
Main Authors: Di Nardo, Giovanna, Breitner, Maximilian, Sadeghi, Sheila J., Castrignanò, Silvia, Mei, Giampiero, Di Venere, Almerinda, Nicolai, Eleonora, Allegra, Paola, Gilardi, Gianfranco
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859599/
https://ncbi.nlm.nih.gov/pubmed/24349198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082118
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