Human Cytochrome P450 3A4 as a Biocatalyst: Effects of the Engineered Linker in Modulation of Coupling Efficiency in 3A4-BMR Chimeras

Human liver cytochrome P450 3A4 is the main enzyme involved in drug metabolism. This makes it an attractive target for biocatalytic applications, such as the synthesis of pharmaceuticals and drug metabolites. However, its poor solubility, stability and low coupling have limited its application in th...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Degregorio, Danilo, D'Avino, Serena, Castrignanò, Silvia, Di Nardo, Giovanna, Sadeghi, Sheila J., Catucci, Gianluca, Gilardi, Gianfranco
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359286/
https://ncbi.nlm.nih.gov/pubmed/28377716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00121
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