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Optimization of the Bacterial Cytochrome P450 BM3 System for the Production of Human Drug Metabolites

Drug metabolism in human liver is a process involving many different enzymes. Among them, a number of cytochromes P450 isoforms catalyze the oxidation of most of the drugs commercially available. Each P450 isoform acts on more than one drug, and one drug may be oxidized by more than one enzyme. As a...

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Библиографические подробности
Главные авторы: Di Nardo, Giovanna, Gilardi, Gianfranco
Формат: Artigo
Язык:Inglês
Опубликовано: Molecular Diversity Preservation International (MDPI) 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546669/
https://ncbi.nlm.nih.gov/pubmed/23443101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms131215901
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