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Inactivation mechanism of N61S mutant of human FMO3 towards trimethylamine
Human flavin-containing monooxygenase 3 (hFMO3) catalyses the oxygenation of a wide variety of compounds including drugs as well as dietary compounds. It is the major hepatic enzyme involved in the production of the N-oxide of trimethylamine (TMAO) and clinical studies have uncovered a striking corr...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5676948/ https://ncbi.nlm.nih.gov/pubmed/29116146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15224-9 |
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