Evidence for an Elevated Aspartate pK(a) in the Active Site of Human Aromatase

Aromatase (CYP19A1), the enzyme that converts androgens to estrogens, is of significant mechanistic and therapeutic interest. Crystal structures and computational studies of this enzyme shed light on the critical role of Asp(309) in substrate binding and catalysis. These studies predicted an elevate...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Di Nardo, Giovanna, Breitner, Maximilian, Bandino, Andrea, Ghosh, Debashis, Jennings, Gareth K., Hackett, John C., Gilardi, Gianfranco
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294484/
https://ncbi.nlm.nih.gov/pubmed/25425647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.595108
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