Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation

Metabolic regulation influences cell proliferation. The influence of pyruvate kinase isoforms on tumor cells has been extensively studied, but whether PKM2 is required for normal cell proliferation is unknown. We examine how PKM2-deletion affects proliferation and metabolism in non-transformed, non-...

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Udgivet i:Mol Cell
Main Authors: Lunt, Sophia Y., Muralidhar, Vinayak, Hosios, Aaron M., Israelsen, William J., Gui, Dan Y., Newhouse, Lauren, Ogrodzinski, Martin, Hecht, Vivian, Xu, Kali, Acevedo, Paula N. Marín, Hollern, Daniel P., Bellinger, Gary, Dayton, Talya L., Christen, Stefan, Elia, Ilaria, Dinh, Anh T., Stephanopoulos, Gregory, Manalis, Scott R., Yaffe, Michael B., Andrechek, Eran R., Fendt, Sarah-Maria, Heiden, Matthew G. Vander
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289430/
https://ncbi.nlm.nih.gov/pubmed/25482511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.10.027
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