Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic cancer remains controversial. To investigate the role of pyruvate kinase in pan...

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Detalhes bibliográficos
Publicado no:Cancer Metab
Main Authors: Yu, Lei, Teoh, Shao Thing, Ensink, Elliot, Ogrodzinski, Martin P., Yang, Che, Vazquez, Ana I., Lunt, Sophia Y.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937848/
https://ncbi.nlm.nih.gov/pubmed/31893043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-019-0205-z
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