Serine one-carbon catabolism with formate overflow

Serine catabolism to glycine and a one-carbon unit has been linked to the anabolic requirements of proliferating mammalian cells. However, genome-scale modeling predicts a catabolic role with one-carbon release as formate. We experimentally prove that in cultured cancer cells and nontransformed fibr...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Meiser, Johannes, Tumanov, Sergey, Maddocks, Oliver, Labuschagne, Christiaan Fred, Athineos, Dimitris, Van Den Broek, Niels, Mackay, Gillian M., Gottlieb, Eyal, Blyth, Karen, Vousden, Karen, Kamphorst, Jurre J., Vazquez, Alexei
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5091358/
https://ncbi.nlm.nih.gov/pubmed/27819051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601273
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