Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic cancer remains controversial. To investigate the role of pyruvate kinase in pan...

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Dettagli Bibliografici
Pubblicato in:Cancer Metab
Autori principali: Yu, Lei, Teoh, Shao Thing, Ensink, Elliot, Ogrodzinski, Martin P., Yang, Che, Vazquez, Ana I., Lunt, Sophia Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937848/
https://ncbi.nlm.nih.gov/pubmed/31893043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-019-0205-z
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