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Haplotype Variations in Glutathione Transferase Zeta 1 Influence the Kinetics and Dynamics of Chronic Dichloroacetate in Children
Dichloroacetate (DCA) is biotransformed by glutathione transferase zeta 1 (GSTZ1), a bifunctional enzyme that, as maleylacetoacetate isomerase (MAAI), catalyzes the penultimate step in tyrosine catabolism. DCA inhibits GSTZ1/MAAI, leading to delayed plasma drug clearance and to accumulation of poten...
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| Publicado en: | J Clin Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4276489/ https://ncbi.nlm.nih.gov/pubmed/25079374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.371 |
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