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Impact of copula directional specification on multi-trial evaluation of surrogate endpoints

Evaluation of surrogate endpoints using patient-level data from multiple trials is the gold standard, where multi-trial copula models are used to quantify both patient-level and trial-level surrogacy. While limited consideration has been given in the literature to copula choice (e.g., Clayton), no p...

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Bibliographische Detailangaben
Veröffentlicht in:J Biopharm Stat
Hauptverfasser: Renfro, Lindsay A., Shang, Hongwei, Sargent, Daniel J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270950/
https://ncbi.nlm.nih.gov/pubmed/24905465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2014.920870
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