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Activation of Phenylalanine Hydroxylase by Phenylalanine Does Not Require Binding in the Active Site

[Image: see text] Phenylalanine hydroxylase (PheH), a liver enzyme that catalyzes the hydroxylation of excess phenylalanine in the diet to tyrosine, is activated by phenylalanine. The lack of activity at low levels of phenylalanine has been attributed to the N-terminus of the protein’s regulatory do...

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Bibliographische Detailangaben
Veröffentlicht in:Biochemistry
Hauptverfasser: Roberts, Kenneth M., Khan, Crystal A., Hinck, Cynthia S., Fitzpatrick, Paul F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270383/
https://ncbi.nlm.nih.gov/pubmed/25453233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501183x
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