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Phenylalanine Binding Is Linked to Dimerization of the Regulatory Domain of Phenylalanine Hydroxylase

[Image: see text] Analytical ultracentrifugation has been used to analyze the oligomeric structure of the isolated regulatory domain of phenylalanine hydroxylase. The protein exhibits a monomer–dimer equilibrium with a dissociation constant of ∼46 μM; this value is unaffected by the removal of the 2...

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Publicat a:Biochemistry
Autors principals: Zhang, Shengnan, Roberts, Kenneth M., Fitzpatrick, Paul F.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251497/
https://ncbi.nlm.nih.gov/pubmed/25299136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501109s
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