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Phosphorylation of phenylalanine hydroxylase increases the rate constant for formation of the activated conformation of the enzyme
Liver phenylalanine hydroxylase (PheH) is an allosteric enzyme that is activated by phenylalanine. The enzyme is also phosphorylated by protein kinase A, but the effects of phosphorylation are unclear. Recent structural studies (Meisburger et al. (2016) J. Amer. Chem. Soc. 138, 6506–6516) support a...
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| Publicado no: | Biochemistry |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6219928/ https://ncbi.nlm.nih.gov/pubmed/30346142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00919 |
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