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Phosphorylation of phenylalanine hydroxylase increases the rate constant for formation of the activated conformation of the enzyme

Liver phenylalanine hydroxylase (PheH) is an allosteric enzyme that is activated by phenylalanine. The enzyme is also phosphorylated by protein kinase A, but the effects of phosphorylation are unclear. Recent structural studies (Meisburger et al. (2016) J. Amer. Chem. Soc. 138, 6506–6516) support a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Biochemistry
Egile Nagusiak: Khan, Crystal A., Fitzpatrick, Paul F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219928/
https://ncbi.nlm.nih.gov/pubmed/30346142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00919
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