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The Kinetic Mechanism of Phenylalanine Hydroxylase: Intrinsic Binding and Rate Constants from Single Turnover Experiments

Phenylalanine hydroxylase (PheH) catalyzes the key step in the catabolism of dietary phenylalanine, its hydroxylation to tyrosine using tetrahydrobiopterin (BH(4)) and O(2). A complete kinetic mechanism for PheH was determined by global analysis of single turnover data in the reaction of PheHΔ117, a...

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Autori principali: Roberts, Kenneth M., Pavon, Jorge Alex, Fitzpatrick, Paul F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572726/
https://ncbi.nlm.nih.gov/pubmed/23327364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301675e
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