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The Kinetic Mechanism of Phenylalanine Hydroxylase: Intrinsic Binding and Rate Constants from Single Turnover Experiments

Phenylalanine hydroxylase (PheH) catalyzes the key step in the catabolism of dietary phenylalanine, its hydroxylation to tyrosine using tetrahydrobiopterin (BH(4)) and O(2). A complete kinetic mechanism for PheH was determined by global analysis of single turnover data in the reaction of PheHΔ117, a...

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Bibliographic Details
Main Authors: Roberts, Kenneth M., Pavon, Jorge Alex, Fitzpatrick, Paul F.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572726/
https://ncbi.nlm.nih.gov/pubmed/23327364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301675e
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