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Single Turnover Kinetics of Tryptophan Hydroxylase: Evidence for a New Intermediate in the Reaction of the Aromatic Amino Acid Hydroxylases

Tryptophan hydroxylase (TrpH) uses a non-heme mononuclear iron center to catalyze the tetrahydropterin-dependent hydroxylation of tryptophan to 5-hydroxytryptophan. The reactions of the TrpH·Fe(II), TrpH·Fe(II)·tryptophan, TrpH·Fe(II)·6MePH(4)·tryptophan, and TrpH·Fe(II)·6MePH(4)·phenylalanine compl...

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Detalhes bibliográficos
Main Authors: Pavon, Jorge Alex, Eser, Bekir, Huynh, Michaela T., Fitzpatrick, Paul F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932755/
https://ncbi.nlm.nih.gov/pubmed/20687613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100744r
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