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Identification of Small Molecule Inhibitors of Pre-mRNA Splicing

Eukaryotic pre-mRNA splicing is an essential step in gene expression for all genes that contain introns. In contrast to transcription and translation, few well characterized chemical inhibitors are available with which to dissect the splicing process, particularly in cells. Therefore, the identifica...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Pawellek, Andrea, McElroy, Stuart, Samatov, Timur, Mitchell, Lee, Woodland, Andrew, Ryder, Ursula, Gray, David, Lührmann, Reinhard, Lamond, Angus I.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2014
Sujets:
RNA
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263873/
https://ncbi.nlm.nih.gov/pubmed/25281741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.590976
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