SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing

Pre-mRNA splicing is catalyzed by the spliceosome, a multi-megadalton ribonucleoprotein machine. Previous work from our laboratory revealed the splicing factor SRSF1 as a regulator of the SUMO pathway, leading us to explore a connection between this pathway and the splicing machinery. We show here t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Pozzi, Berta, Bragado, Laureano, Will, Cindy L., Mammi, Pablo, Risso, Guillermo, Urlaub, Henning, Lührmann, Reinhard, Srebrow, Anabella
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2017
Pynciau:
RNA
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499870/
https://ncbi.nlm.nih.gov/pubmed/28379520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx213
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